Synthesis and evaluation of some pyrimidine analogs against toxoplasmosis

摘要: Toxoplasmosis is a worldwide infection caused by the obligate intracellular protozoan parasite Toxoplasma gondii. Some pyrimidine analogs were synthesized to be evaluated for their antitoxoplasma effects in animal experiments. Results assessed studying density, estimation of serum antigen, ultrastructural changes parasite, and histopathological affected organs inhibitory activity dihydrofolate reductase (DHFR) isolated from Cryptosporidium parvum. The result showed that 4 out 12 compounds have promising potentials. animals received these four statistically significant decrease mean number count liver spleen when compared corresponding control group. Moreover, antigen was very low or even absent receiving compounds. Light microscopic examination peritoneal exudates stoppage movement deformity shape tachyzoites, whereas scanning electron microscopy revealed organisms had lost crescent shape, with dimples deep ridges on surfaces. Very mild noticed liver, spleen, lungs groups comparison other groups. Thus, proved effectiveness eradication experimental inhibition DHFR C.