The epidemiology of narcolepsy.

摘要: Much has been learned about the pathophysiology of narcolepsy over last several decades. It is likely that hypocretin-producing cells in lateral hypothalamus are selectively destroyed genetically susceptible individuals carrying 1 or more alleles HLA DQB1*0602. Despite advances, causes and how to prevent it remain elusive. Classic epidemiology aims not only enumerate occurrence disease populations, but also identify etiologic risk factors. This review details what application classic taught us so far suggests directions for future studies clarify its etiology. The prevalence with cataplexy examined many falls between 25 50 per 100,000 people. Information on incidence limited, study finding be 0.74 person-years. search factors yet yield important associations. Factors most thoroughly include body mass index, immune responses, stressful life events. Such associations may reflect a consequence rather than cause disease. As other diseases characterized by selective cell loss, such as Parkinson type diabetes mellitus, caused environmental exposures before age onset individuals. Matching efforts these using large well-designed epidemiologic narcolepsy, investigators must intensify exposures, focusing first 2 decades life. Identification modifiable will help this