Blockade of EGFR signaling promotes glioma stem-like cell invasiveness by abolishing ID3-mediated inhibition of p27KIP1 and MMP3 expression
作者： Xun Jin , Xiong Jin , Young-Woo Sohn , Jinlong Yin , Sung-Hak Kim
DOI: 10.1016/J.CANLET.2012.09.005
关键词:
摘要: Aberrant epidermal growth factor receptor (EGFR) signaling is a typical oncogenic signature in glioblastoma. Here, we show that EGFR inhibition primary glioma stem cells (GSCs) with EGFRvIII and EGFRvIII-transduced stem-like promotes invasion by decreasing ID3 levels. suppresses GSC invasiveness inhibiting p27(KIP1)-RhoA-dependent migration MMP3 expression. Xenograft human glioblastoma specimens localizes within cores, whereas p27(KIP1) are predominantly expressed invasive fronts. Together, our findings induces abolishing ID3-mediated of
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sci-hub.se 参考文章(46)
Benedikte Hasselbalch, Jesper Grau Eriksen, Helle Broholm, Ib Jarle Christensen, Kirsten Grunnet, Michael R. Horsman, Hans Skovgaard Poulsen, Marie-Thérése Stockhausen, Ulrik Lassen, Prospective evaluation of angiogenic, hypoxic and EGFR-related biomarkers in recurrent glioblastoma multiforme treated with cetuximab, bevacizumab and irinotecan. Apmis. ,vol. 118, pp. 585- 594 ,(2010) , 10.1111/J.1600-0463.2010.02631.X
Sidney M. Hecht, Jeffrey A. Smith, Deborah A. Lannigan, Yaming Xu, Celeste E. Poteet-Smith, Timothy M. Errington, Identification of the First Specific Inhibitor of p90 Ribosomal S6 Kinase (RSK) Reveals an Unexpected Role for RSK in Cancer Cell Proliferation Cancer Research. ,vol. 65, pp. 1027- 1034 ,(2005)
Francesco Niola, Xudong Zhao, Devendra Singh, Angelica Castano, Ryan Sullivan, Mario Lauria, Hyung-song Nam, Yuan Zhuang, Robert Benezra, Diego Di Bernardo, Antonio Iavarone, Anna Lasorella, Id proteins synchronize stemness and anchorage to the niche of neural stem cells. Nature Cell Biology. ,vol. 14, pp. 477- 487 ,(2012) , 10.1038/NCB2490
A-A Chassot, L Turchi, T Virolle, G Fitsialos, M Batoz, M Deckert, V Dulic, G Meneguzzi, R Buscà, G Ponzio, Id3 is a novel regulator of p27kip1 mRNA in early G1 phase and is required for cell-cycle progression. Oncogene. ,vol. 26, pp. 5772- 5783 ,(2007) , 10.1038/SJ.ONC.1210386
Manabu Onishi, Tomotsugu Ichikawa, Kazuhiko Kurozumi, Isao Date, Angiogenesis and invasion in glioma. Brain Tumor Pathology. ,vol. 28, pp. 13- 24 ,(2011) , 10.1007/S10014-010-0007-Z
J. D. Dignam, R. M. Lebovitz, R. G. Roeder, Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei Nucleic Acids Research. ,vol. 11, pp. 1475- 1489 ,(1983) , 10.1093/NAR/11.5.1475
Anna Häger, Stephanie Alexander, Peter Friedl, Cancer invasion and resistance Ejc Supplements. ,vol. 11, pp. 291- 293 ,(2013) , 10.1016/J.EJCSUP.2013.07.055
Incheol Shin, F Michael Yakes, Federico Rojo, Nah-Young Shin, Andrei V. Bakin, Jose Baselga, Carlos L. Arteaga, PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization. Nature Medicine. ,vol. 8, pp. 1145- 1152 ,(2002) , 10.1038/NM759
Ichiro Nakano, Harley I Kornblum, Brain tumor stem cells. Pediatric Research. ,vol. 59, pp. 54- 58 ,(2006) , 10.1203/01.PDR.0000203568.63482.F9
Amy B. Heimberger, Roman Hlatky, Dima Suki, David Yang, Jeff Weinberg, Mark Gilbert, Raymond Sawaya, Kenneth Aldape, Prognostic effect of epidermal growth factor receptor and EGFRvIII in glioblastoma multiforme patients. Clinical Cancer Research. ,vol. 11, pp. 1462- 1466 ,(2005) , 10.1158/1078-0432.CCR-04-1737