L-Carnitine supplementation improved clinical status without changing oxidative stress and lipid profile in women with knee osteoarthritis.

摘要: Considering the pathologic importance of oxidative stress and altered lipid metabolism in osteoarthritis (OA), this study aimed to investigate effect l-carnitine supplementation on stress, profile, clinical status women with knee OA. We hypothesized that would improve by modulating serum profile. In randomized double-blind, placebo-controlled trial, 72 overweight or obese mild moderate OA were randomly allocated into 2 groups receive 750 mg/d placebo for 8 weeks. Dietary intake was evaluated using 24-hour recall 3 days. Serum malondialdehyde (MDA), total antioxidant capacity (TAC) visual analog scale pain intensity, patient global assessment severity disease assessed before after supplementation. Only 69 patients (33 group 36 group) completed study. l-Carnitine resulted significant reductions MDA (2.46 ± 1.13 vs 2.16 0.94 nmol/mL), cholesterol (216.09 34.54 206.12 39.74 mg/dL), low-density lipoprotein (129.45 28.69 122.05 32.76 mg/dL) levels compared baseline (P .05). No differences observed dietary intake, MDA, TAC between adjusting values covariates > There intragroup intergroup intensity < Collectively, improved without changing profile significantly