Copper(II)‐Catalyzed CC Bond‐Forming Reactions of α‐Electron‐Withdrawing Group‐Substituted Ketene S,S‐Acetals with Carbonyl Compounds and a Facile Synthesis of Coumarins
作者： Hong-Juan Yuan , Mang Wang , Ying-Jie Liu , Qun Liu
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摘要: A new catalytic CC bond-forming reaction has been developed. Catalyzed by cheap and commercially available copper(II) bromide (CuBr2; 10 mol%), the reactions of α-electron-withdrawing group (EWG)-substituted ketene S,S-acetals with aldehydes or ketones in acetonitrile at room temperature gave a variety densely functionalized coupling products excellent yields (80–98%). Based on this process, coumarin derivatives were efficiently synthesized when salicylaldehydes selected as carbonyl components.
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