Inter- and intra-observer variability in grading lesions of age-related maculopathy and macular degeneration.

摘要: To introduce a revised version of the grading system established by International ARM Epidemiological Study Group for identifying and quantifying abnormalities age-related maculopathy (ARM) degeneration (AMD) to investigate its reliability, specifically inter- intra-observer variability. Fifty eyes 25 patients with or AMD in at least one eye were randomly selected from large ongoing collection clinical data DNA tertiary referral UK population. Stereoscopic color fundus photographs taken 30° camera centered on macula. Presence severity graded using grid define macular subfields standard circles size lesions. Inter-observer variability was assessed having three retinal specialists evaluate slides re-grading same set. The inter-observer agreement all fair substantial small hard drusen (70–89%; κ=0.26–0.63) intermediate soft (76–94%; κ=0.27–0.69). Agreement ranged between 87% 100%, 50% 92%, 78% 100% larger drusen, presence hyperpigmentation, hypopigmentation, respectively. moderate almost perfect geographic atrophy (88–98%; κ=0.60–0.95) choroidal neovascularization (84–100%; κ=0.62–1.00). characteristics pigmentary changes similar magnitude, but slightly greater features advanced AMD. Reproducibility achieved Group. This may therefore be used phenotyping