Determination of endogenous concentrations of the lanthanides in body fluids and tissues using electrothermal vaporization inductively coupled plasma mass spectrometry

摘要: A method was developed for the determination of endogenous concentrations lanthanides in body fluids and tissues with electrothermal vaporization inductively coupled plasma mass spectrometry. The applied to analysis rat liver human blood as well some reference materials,viz., Oyster Tissue, Bovine Liver, Seronorm Trace Element Serum Human Hair. Microwave digestion high-pressure containers used digest various biological materials. Analyses undigested by slurry sampling direct injection were also performed. For samples, hydrogen peroxide injected directly onto sample inside graphite furnace found be effective preventing build-up ash furnace. Trifluoromethane (Freon-23) an chemical modifier that lowered temperature memory effect significantly most lanthanides. absolute detection limits were, few exceptions, range 1–20 fg all relative varied level dilution used. Serum, 0.05–1.2 ng l–1. analytical results digested samples same material similar respect accuracy precision. intermediate precision, i.e., overall standard deviation obtained CRMs analysed on three different (not consecutive) days, less than 25% higher 1 g–1 dry material. In cases where a certified or indicative value existed materials, good agreement between these present work found. Blood from 30 healthy volunteers ten unexposed rats analysed. All above limit