Regulation of signal transduction cascades by Pterostilbenes in different cancers: Is it a death knell for oncogenic pathways.

摘要: Interdisciplinary research has revolutionized the field of medicine and we have witnessed exponential increase in high-impact past few decades. However, road to this burgeoning is obstacle-ridden because intratumor heterogeneity, loss apoptosis dysregulation spatio-temporally controlled signaling pathways. Ground-breaking findings obtained through genetic, genomic proteomic studies considerably improved our concepts related complexity protein network excitingly, discovery miRNAs added another layer intricacy quantitatively regulated gene networks. In review, chronicle milestone achievements discuss how Pterostilbenes effectively different cellular We provided detailed mechanistic insights regulation JAK-STAT signaling, Notch pathway, Wnt mediated intracellular by pterostilbene. Underlying mechanisms about PI3K/AKT MAPK pathways pterostilbene cancers.  Regulation Metastasis-associated 1 (MTA1) proteins Human telomerase reverse transcriptase (hTERT) cancer cells Pterostilbene also been reported modulate expression various oncogenic tumor suppressor microRNAs cells. Better sharper comprehension associated with modes action cancers will be useful identification which can efficiently targeted