Enterotoxigenic Escherichia coli (ETEC) in farm animals

作者: Béla Nagy , Péter Zs. Fekete

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摘要: Animal diseases due to enterotoxigenic Escherichia coli (ETEC) typically appear as severe watery diarrhoea during the first few days of life (also a after weaning in pigs). ETEC adhere small intestinal microvilli without inducing morphological lesions and produce enterotoxins acting locally on enterocytes. This action results hypersecretion (of water electrolytes) reduced absorption. Adhesins toxins are two prominent virulence attributes level knowledge these factors determines chances for successful prevention therapy disease. For animal most common adhesins fimbriae (pili) surface: F4(K88), F5(K99), F6(987P), F41, F42, F165, F17 F18. Enterotoxins (extracellular proteins or peptides) classified heat-labile (LT) heat-stable (ST) with further subdivisions (LTh-I, LTp-I, LTIIa, LTIIb, STaH, STaP, STb) according antigenic biological differences. Fimbriae LT made up large molecular weight which facilitate their utilisation vaccines detection using immunodiagnostic systems. The adhesive plasmid determined (except F41 F17). Virulence gene probes (DNA hybridisation, PCR) specific sensitive diagnostic epidemiologic tools ETEC. Based genetic typing, ETEC, spite limited serogroups, seem represent population E. diverse background.

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