Function and Redox State of Peritoneal Leukocytes as Preclinical and Prodromic Markers in a Longitudinal Study of Triple-Transgenic Mice for Alzheimer's Disease

摘要: The aging process involves the impairment of immune system (immunosenescence), based on imbalance redox status, as occurs in neurodegenerative diseases such Alzheimer's disease (AD). Since AD there is a systemic disorder, we aimed to assess longitudinally, from before onset until complete establishment AD, cell populations, several functions, and oxidative stress parameters peritoneal leukocytes triple transgenic mice for (3xTgAD). These animals mimic human pathophysiology. results indicate premature immunosenescence 3xTgAD at 4 months age, when immunoreactivity against intracellular amyloid- fibrils appears. Thus, decreases functions chemotaxis, phagocytosis, lymphoproliferation, well lower reduced glutathione content higher xanthine oxidase activity, appear leukocytes. Moreover, NK percentage cytotoxic CD25+ B na¨ ive CD8 T cells percentage, GSSG/GSH ratio, GSH were already changed age 2 months. Furthermore, changes some CD5+ B1 cells, activity continue 15 pathophysiology completely established. Because studied are markers health longevity, could explain shorter life span shown by observed present work. suggest that peripheral their status be good early preclinical prodromal stages progression AD.