Mortality associated with depression as compared with other severe mental disorders: A 20-year follow-up study of the GAZEL cohort.

摘要: Individuals with severe mental disorders (SMD) have an increased risk of mortality from somatic diseases. This study examined whether this is different in persons depressive compared to those other SMD (i.e. schizophrenia and bipolar disorder). In 1989, 20,625 employees the French national gas electricity company (15,011 men 5614 women, aged 35-50) agreed participate GAZEL cohort study. Three diagnosis groups were created based on sick leave spells 1978 onwards: 1) no SMD, 2) 3) SMD. Dates causes death available January 1, 1990 December 31, 2010. The association was estimated hazard ratios (HR) 95% confidence intervals (CI) computed using Cox regression. During a mean follow-up 19.8 years, 1544 participants died, including 1343 natural cause, which 258 died cardiovascular After adjustment for age, gender, occupational status, alcohol consumption, smoking body-mass index, history sickness absence had greater (HR: 1.24, CI: 1.08-1.43), 1.49, 1.08-2.05) non-cardiovascular 1.19, 1.02-1.39). Compared disorders, associated 1.94, 1.17-3.22) 3.58, 1.53-8.39). Job security systematic medical may fall short preventing premature among workers due