Methodology and Applications of Disease Biomarker Identification in Human Serum

摘要: Biomarkers are biomolecules that serve as indicators of biological and pathological processes, or physiological pharmacological responses to a drug treatment. Because the high abundance albumin heterogeneity plasma lipoproteins glycoproteins, biomarkers difficult identify in human serum. Due clinical significance identification disease serum holds great promise for personalized medicine, especially diagnosis prognosis. This review summarizes some common emerging proteomics techniques utilized separation samples signatures. The practical application each protein technique is analyzed using specific examples. cancers prostate, breast, ovary, lung have been reviewed, well those heart disease, arthritis, asthma, cystic fibrosis. Despite advancement technology few approved by Food Drug Administration prognosis due complexity structure function lack sensitivity, specificity, reproducibility putative biomarkers. combination different types technologies statistical analysis may provide more effective methods validate new blood.