摘要: Count data, or number of events per time interval, are discrete data arising from repeated to event observations. Their mean count, piecewise constant rate, can be evaluated by probability distributions the Poisson model family. Clinical trial characterization often involves population count analysis. This tutorial presents basics and diagnostics modeling simulation in context pharmacometrics. Consideration is given overdispersion, underdispersion, autocorrelation, inhomogeneity.
sci-hub.se 参考文章(59)
Nozer D Singpurwalla, The hazard potential: Introduction and overview Journal of the American Statistical Association. ,vol. 101, pp. 1705- 1717 ,(2006) , 10.1198/016214506000001068
William Gardner, Edward P. Mulvey, Esther C. Shaw, Regression analyses of counts and rates: Poisson, overdispersed Poisson, and negative binomial models. Psychological Bulletin. ,vol. 118, pp. 392- 404 ,(1995) , 10.1037/0033-2909.118.3.392
DR Mould, RN Upton, Basic concepts in population modeling, simulation, and model-based drug development-part 2: introduction to pharmacokinetic modeling methods. CPT: Pharmacometrics & Systems Pharmacology. ,vol. 2, pp. 1- 14 ,(2013) , 10.1038/PSP.2013.14
Donald Olivier, Nan Laird, Covariance Analysis of Censored Survival Data Using Log-Linear Analysis Techniques Journal of the American Statistical Association. ,vol. 76, pp. 231- 240 ,(1981) , 10.1080/01621459.1981.10477634
Elodie L. Plan, Alan Maloney, Iñaki F. Trocóniz, Mats O. Karlsson, Performance in population models for count data, part I: maximum likelihood approximations Journal of Pharmacokinetics and Pharmacodynamics. ,vol. 36, pp. 353- 366 ,(2009) , 10.1007/S10928-009-9126-8
D. M. Jonker, C. van de Mheen, P. H. C. Eilers, M. R. Kruk, R. A. Voskuyl, M. Danhof, Anticonvulsant drugs differentially suppress individual ictal signs: a pharmacokinetic/pharmacodynamic analysis in the cortical stimulation model in the rat. Behavioral Neuroscience. ,vol. 117, pp. 1076- 1085 ,(2003) , 10.1037/0735-7044.117.5.1076
Mats O. Karlsson, Stuart L. Beal, Lewis B. Sheiner, Three new residual error models for population PK/PD analyses Journal of Pharmacokinetics and Biopharmaceutics. ,vol. 23, pp. 651- 672 ,(1995) , 10.1007/BF02353466
Maud Delattre, Radojka M. Savic, Raymond Miller, Mats O. Karlsson, Marc Lavielle, Analysis of exposure–response of CI-945 in patients with epilepsy: application of novel mixed hidden Markov modeling methodology Journal of Pharmacokinetics and Pharmacodynamics. ,vol. 39, pp. 263- 271 ,(2012) , 10.1007/S10928-012-9248-2
Malcolm Rowland, Leslie Z. Benet, Sidney Riegelman, Two-Compartment Model for a Drug and Its Metabolite: Application to Acetylsalicylic Acid Pharmacokinetics Journal of Pharmaceutical Sciences. ,vol. 59, pp. 364- 367 ,(1970) , 10.1002/JPS.2600590319
Lars Lindbom, Pontus Pihlgren, Niclas Jonsson, PsN-Toolkit-A collection of computer intensive statistical methods for non-linear mixed effect modeling using NONMEM Computer Methods and Programs in Biomedicine. ,vol. 79, pp. 241- 257 ,(2005) , 10.1016/J.CMPB.2005.04.005