CYTOKINETIC ANALYSIS OF TUMOR GROWTH

摘要: The growth of cell populations rarely follows a constant and inexorable course. Rather, the over-all rate usually shifts in characteristic fashion with times appropriate to particular population: from rapid slow even on occasion no or negative growth. reasons for this are far clear. Population represents summation birth death loss functions. Knowledge fine structure pattern population may therefore provide important insight about nature rate-controlling factors. present investigation was undertaken determine cytokinetic basis change as tumor increases size. It found earlier work ascites tumors mice' -3 that appeared be function mainly total number free cells. initial, comparatively brief phase proliferation followed by progressive deceleration toward an asymptote. Several factors contribute deceleration: (1) increase duration mitotic cycle; (2) gradual decline fraction; (3) either migration. Although some attention has been given cycle4-8 fraction9-'2 during development, precise connection variables noted above curve not established.