Dietary Modulation of Colon Cancer: Effects on Intermediary Metabolism, Mucosal Cell Differentiation, and Inflammation

摘要: We review the profound effects that components of diets commonly consumed in western societies and linked through population studies to risk for colon cancer have on development intestinal humans mouse models. Focus is particularly levels vitamin D, interactive with calcium fat, establishing probability tumor even genetic models which there high penetrance disease. These dietary factors also been used develop a model dietary-induced sporadic exhibits similar lag, incidence, frequency development, relative incidence carcinomas adenomas, as seen >90% tumors arise general later life. Potential mechanisms influenced by diet alter are outlined, including altered patterns intermediary metabolism, differentiation, inflammation mucosa, all apparent histopathologically normal mucosa well before neoplastic changes become detectable. This includes pathways macrophages signal epithelial cells, revealing new paradigm how D may influence development.