Neural plasticity and addiction: PI3-kinase and cocaine behavioral sensitization.
作者： Emanuela Izzo , Rémi Martin-Fardon , George F. Koob , Friedbert Weiss , Pietro Paolo Sanna
DOI: 10.1038/NN977
关键词:
摘要: Drug addiction has been linked to protracted functional changes in neural circuits involved motivation that can lead drug dependence, craving and relapse1. Here we investigated the role of phosphatidylinositol 3 kinase (PI3K) signal transduction pathway long-lasting behavioral sensitization cocaine rats, an animal model induced by repeated use2. Our results show PI3K is required for expression, but not induction, cocaine.
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