Design und Anwendung eines von Campher abgeleiteten Methylketon-Enolats für hoch stereoselektive „Acetat”-Aldolreaktionen
作者： Claudio Palomo , Alberto González , Jesús M. García , Cristina Landa , Mikel Oiarbide
DOI: 10.1002/(SICI)1521-3757(19980116)110:1/2<190::AID-ANGE190>3.0.CO;2-W
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摘要: Dicht am chiralen Auxiliar vorbei verlauft die Einflugschneise des elektrophilen Aldehyds beim Angriff auf das Lithium-Enolat von II. Dementsprechend wurden bei der Aldolreaktion mit II und einer Vielzahl Aldehyden Diastereomerenuberschusse in Regel 95–98 % erreicht. Die chirale Hilfsgruppe Campher kann dieser Methylketon-Enolat-Strategie nach Reaktion zuruckgewonnen werden.
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