Cell cycle deregulation: a common motif in cancer.

摘要: Uncontrolled proliferation is a hallmark of cancer cells. Molecular analysis human tumors and animal models have provided clear basis for the understanding cellular processes that govern cell cycle progression in normal tumor Many regulators controlling correct entry through are altered tumors. In fact, most, if not all, cancers show deregulated control G1 progression, period when cells decide whether to start or stay quiescent. addition, impaired checkpoints, resulting accumulation genetic aberrations. Manipulation these mechanisms provides new avenues design advanced therapeutic strategies against development.