Protein Phosphatase 6 Controls BCR-Induced Apoptosis of WEHI-231 Cells by Regulating Ubiquitination of Bcl-xL

摘要: Crosslinking BCR in the immature B cell line WEHI-231 causes apoptosis. We found that Bcl-xL was degraded by polyubiquitination upon crosslinking and this study explored mechanism controls degradation of Bcl-xL. Ser62 phosphorylated JNK to trigger polyubiquitination, opposed serine/threonine protein phosphatase 6 (PP6) physically associated with show decreased PP6 activity allow phosphorylation CD40 rescues BCR-induced apoptosis, we activation response CD40. Our data suggest is regulated control apoptosis modulating Bcl-xL, which results its degradation.