High-Throughput Screening Platforms in the Discovery of Novel Drugs for Neurodegenerative Diseases.

作者: Hasan Aldewachi , Radhwan N Al-Zidan , Matthew T Conner , Mootaz M Salman , None

DOI: 10.3390/BIOENGINEERING8020030

关键词:

摘要: … The screening attrition rate in current drug discovery … the use of efficient high-throughput screening (HTS) becomes … evolved to improve screening efficiency with higher predictability and …

参考文章(170)
Michael R. Wyler, Deborah H. Smith, Eftihia Cayanis, Udo Többen, Nathalie Aulner, Thomas Mayer, Cell-Based Assays to Probe the ERK MAP Kinase Pathway in Endothelial Cells Methods in Molecular Biology. ,vol. 486, pp. 29- 41 ,(2009) , 10.1007/978-1-60327-545-3_3
Susan Duty, Peter Jenner, Animal models of Parkinson's disease: a source of novel treatments and clues to the cause of the disease British Journal of Pharmacology. ,vol. 164, pp. 1357- 1391 ,(2011) , 10.1111/J.1476-5381.2011.01426.X
Jorge Ivan Alvarez, Takahiro Katayama, Alexandre Prat, Glial influence on the blood brain barrier. Glia. ,vol. 61, pp. 1939- 1958 ,(2013) , 10.1002/GLIA.22575
Alexander McGown, Jonathan R. McDearmid, Niki Panagiotaki, Huaxia Tong, Sufana Al Mashhadi, Natasha Redhead, Alison N. Lyon, Christine E. Beattie, Pamela J. Shaw, Tennore M. Ramesh, Early Interneuron Dysfunction in ALS: Insights from a Mutant sod1 Zebrafish Model Annals of Neurology. ,vol. 73, pp. 246- 258 ,(2013) , 10.1002/ANA.23780
Brent R. Stockwell, Hemant Varma, Donald C. Lo, High-Throughput and High-Content Screening for Huntington’s Disease Therapeutics CRC Press/Taylor & Francis. ,(2011)
Debby Van Dam, Peter Paul De Deyn, Animal models in the drug discovery pipeline for Alzheimer's disease. British Journal of Pharmacology. ,vol. 164, pp. 1285- 1300 ,(2011) , 10.1111/J.1476-5381.2011.01299.X
Rahasson R. Ager, Joy L. Davis, Andy Agazaryan, Francisca Benavente, Wayne W. Poon, Frank M. LaFerla, Mathew Blurton‐Jones, Human neural stem cells improve cognition and promote synaptic growth in two complementary transgenic models of Alzheimer's disease and neuronal loss Hippocampus. ,vol. 25, pp. 813- 826 ,(2015) , 10.1002/HIPO.22405
Jessica Cherian, Dylan Atkinson, Krishna R Patel, Kunj Gohil, Schizophrenia: Overview and Treatment Options P & T : a peer-reviewed journal for formulary management. ,vol. 39, pp. 638- 645 ,(2014)
Edward C. Hulme, Mike A. Trevethick, Ligand binding assays at equilibrium: validation and interpretation. British Journal of Pharmacology. ,vol. 161, pp. 1219- 1237 ,(2010) , 10.1111/J.1476-5381.2009.00604.X
Punita Sharma, D.Michael Ando, Aaron Daub, Julia A. Kaye, Steven Finkbeiner, High-throughput screening in primary neurons. Methods in Enzymology. ,vol. 506, pp. 331- 360 ,(2012) , 10.1016/B978-0-12-391856-7.00041-X