Endoscopic studies of nabumetone in patients with rheumatoid arthritis

摘要: Gastric tolerance to 1 g of nabumetone administered in a single nightly dose was assessed two trials patients with rheumatoid arthritis. Gastroscopy and histology mucosal biopsy specimens were performed before after the end treatment both trials. Trial an open study that compared effects at night those naproxen (dose, 500 mg twice daily) indomethacin 50 three times 41 hospitalized patients. After weeks treatment, significantly better tolerated than or indomethacin. 2 randomized trial 24 per group given 250 morning for period months. This single-blind revealed number microscopic macroscopic lesions smaller following intake nabumetone. Concerning efficacy, as judged clinically by rheumatologist, superior well.