Determination of cocaine and methadone in urine samples by thin-film solid-phase microextraction and direct analysis in real time (DART) coupled with tandem mass spectrometry
作者： Angel Rodriguez-Lafuente , Fatemeh S. Mirnaghi , Janusz Pawliszyn
DOI: 10.1007/S00216-013-6993-Z
关键词:
摘要: The use of thin-film solid-phase microextraction (SPME) as the sampling preparation step before direct analysis in real time (DART) was evaluated for determination two prohibited doping substances, cocaine and methadone, urine samples. Results showed that SPME improves detectability these compounds: signal-to-blank ratios 5 (cocaine) 13 (methadone) were obtained 0.5 ng/ml human urine. Thin-film also provides efficient sample cleanup, avoiding contamination ion source by salt residues from Extraction established 10 min, thus providing relatively short high throughput when combined with a 96-well shaker coupled DART technique.
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