Carboxamides as N‐Alkylating Reagents of Secondary Amines in Indium‐Catalyzed Reductive Amination with a Hydrosilane
作者： Yohei Ogiwara , Wataru Shimoda , Keisuke Ide , Takumi Nakajima , Norio Sakai
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摘要: A method for the catalytic reductive N-alkylation of amines by using secondary amides as alkyl source was developed. versatile type carboxamide functioned an reagent in presence indium(III) catalyst and a hydrosilane to provide alkylated tertiary efficiently. This amide-based strategy is considered be highly useful protocol access unsymmetrical amines.
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