Insulinotropic action of meglitinide analogs: concentration-response relationship and nutrient dependency.

摘要: The insulinotropic action of meglitinide was compared to that its analogs S 3075, A-4166, KAD-1229 and repaglinide. None these hypoglycemic agents significantly enhanced insulin output from rat pancreatic islets incubated for 90 min in the absence exogenous nutrient. However, all agents, when tested at a 10 microM concentration, augmented release evoked by either 7 mM D-glucose or succinic acid monomethyl ester (SAM). In this respect, less efficient secretagogue than other non-sulfonylurea agents. Moreover, presence D-glucose, lowest concentration drug required cause significant increase decreased about 1.0 0.1 with repaglinide even close nM case 3075. concentration-response relationship thus yielded following hierarchy, 3075 > = A-4166 meglitinide, there being difference more two orders magnitude between weakest most potent agent.