Activation of Spinal Glucagon-Like Peptide-1 Receptors Specifically Suppresses Pain Hypersensitivity
作者： N. Gong , Q. Xiao , B. Zhu , C.-Y. Zhang , Y.-C. Wang
DOI: 10.1523/JNEUROSCI.4703-13.2014
关键词:
摘要: This study aims to identify the inhibitory role of spinal glucagon like peptide-1 receptor (GLP-1R) signaling in pain hypersensitivity and its mechanism action rats mice. First, GLP-1Rs were identified be specifically expressed on microglial cells dorsal horn, profoundly upregulated after peripheral nerve injury. In addition, intrathecal GLP-1R agonists GLP-1(7-36) exenatide potently alleviated formalin-, injury-, bone cancer-, diabetes-induced states by 60-90%, without affecting acute nociceptive responses. The antihypersensitive effects GLP-1 completely prevented antagonism gene knockdown. Furthermore, evoked β-endorphin release from both cord cultured microglia. Exenatide antiallodynia was inhibitor minocycline, antiserum, opioid antagonist naloxone. Our results illustrate a novel horn GLP-1R/β-endorphin pathway variety states.
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