Morphometric evidence for non-pressure-related arterial wall thickening in hypertension.

摘要: To investigate the relation of pressure and vascular wall thickening in hypertension, we coarcted abdominal aorta upstream to renal arteries 14 rats. Sham-coarcted (n = 16) two-kidney, one-clip (Goldblatt) hypertensive rats 13) served as controls. Tail, femoral, carotid arterial pressures rose (p less than 0.01) hypertensives; only rats, tail femoral remaining normal greater 0.25). Thus, hindquarters remained normotensive. Four six weeks after surgery perfusion-fixed tissues hindquarters, including kidneys, with formalin at vivo levels pressure. Glycol methacrylate-embedded were sectioned 1 micron thickness vessels quantitatively evaluated. The outer medial lumen perimeters aorta, artery, arterioles measured; from these measurements, vessel diameters, thickness, area, thickness-to-lumen radius ratios calculated. Compared sham-coarcted arteries, 61 microns diameter coarctation Goldblatt hypertension had significantly increased (up +100%) ratios. In general, magnitudes abnormalities similar Renal 60 outside hypertensive, but not coarcted, also thickened. These results indicate that occurs conduit smaller normotensive providing morphometric evidence for non-pressure-related mechanisms involved growth this form hypertension.