Genotype-phenotype relationship in Brugada syndrome: electrocardiographic features differentiate SCN5A-related patients from non–SCN5A-related patients

作者: Jeroen P.P Smits , Lars Eckardt , Vincent Probst , Connie R Bezzina , Jean Jacques Schott

DOI: 10.1016/S0735-1097(02)01962-9

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摘要: … evident between SCN5A-related and non–SCN5A-related patients after drug administration; SCN5A-related patients had a significantly longer QRS interval than non–SCN5A-related …

参考文章(20)
Qiuyun Chen, Glenn E. Kirsch, Danmei Zhang, Ramon Brugada, Josep Brugada, Pedro Brugada, Domenico Potenza, Angel Moya, Martin Borggrefe, Günter Breithardt, Rocio Ortiz-Lopez, Zhiqing Wang, Charles Antzelevitch, Richard E. O'Brien, Eric Schulze-Bahr, Mark T. Keating, Jeffrey A. Towbin, Qing Wang, Genetic basis and molecular mechanism for idiopathic ventricular fibrillation Nature. ,vol. 392, pp. 293- 296 ,(1998) , 10.1038/32675
Jean-Jacques Schott, Connie Alshinawi, Florence Kyndt, Vincent Probst, Theo M. Hoorntje, Miriam Hulsbeek, Arthur A.M. Wilde, Denis Escande, Marcel M.A.M. Mannens, Hervé Le Marec, Cardiac conduction defects associate with mutations in SCN5A. Nature Genetics. ,vol. 23, pp. 20- 21 ,(1999) , 10.1038/12618
Alistair C Jones, Jehannine Austin, Nancy Hansen, Bastiaan Hoogendoorn, Peter J Oefner, Jeremy P Cheadle, Michael C O’Donovan, Optimal Temperature Selection for Mutation Detection by Denaturing HPLC and Comparison to Single-Stranded Conformation Polymorphism and Heteroduplex Analysis Clinical Chemistry. ,vol. 45, pp. 1133- 1140 ,(1999) , 10.1093/CLINCHEM/45.8.1133
WATARU SHIMIZU, CHARLES ANTZELEVITCH, KAZUHIRO SUYAMA, TAKASHI KURITA, ATSUSHI TAGUCHI, NAOHIKO AIHARA, HIROSHI TAKAKI, KENJI SUNAGAWA, SHIRO KAMAKURA, Effect of Sodium Channel Blockers on ST Segment, QRS Duration, and Corrected QT Interval in Patients with Brugada Syndrome Journal of Cardiovascular Electrophysiology. ,vol. 11, pp. 1320- 1329 ,(2000) , 10.1046/J.1540-8167.2000.01320.X
JOSEP BRUGADA, PEDRO BRUGADA, Further Characterization of the Syndrome of Right Bundle Branch Block, ST Segment Elevation, and Sudden Cardiac Death Journal of Cardiovascular Electrophysiology. ,vol. 8, pp. 325- 331 ,(1997) , 10.1111/J.1540-8167.1997.TB00796.X
Markus Grompe, The rapid detection of unknown mutations in nucleic acids Nature Genetics. ,vol. 5, pp. 111- 117 ,(1993) , 10.1038/NG1093-111
Bortolo Martini, Andrea Nava, Bruno Canciani, Gaetano Thiene, Right Bundle Branch Block, Persistent ST Segment Elevation and Sudden Cardiac Death Journal of the American College of Cardiology. ,vol. 22, pp. 633- ,(1993) , 10.1016/0735-1097(93)90082-C
AKIRA FUJIKI, MASAHIRO USUI, HIDEHIKO NAGASAWA, KOICHI MIZUMAKI, HIDEKI HAYASHI, HIROSHI INOUE, ST segment elevation in the right precordial leads induced with class IC antiarrhythmic drugs: insight into the mechanism of Brugada syndrome. Journal of Cardiovascular Electrophysiology. ,vol. 10, pp. 214- 218 ,(1999) , 10.1111/J.1540-8167.1999.TB00662.X
Qing Wang, Zhizhong Li, Jiaxiang Shen, Mark T. Keating, Genomic organization of the human SCN5A gene encoding the cardiac sodium channel. Genomics. ,vol. 34, pp. 9- 16 ,(1996) , 10.1006/GENO.1996.0236