Idiopathic pulmonary fibrosis. Abnormalities in the bronchoalveolar lavage content of surfactant protein A.

摘要: Idiopathic pulmonary fibrosis (IPF) is a progressive disease of the lung characterized by an inflammatory infiltrate, alveolar type II cell hypertrophy and hyperplasia, ultimate parenchymal scarring. The phospholipid composition surface-active material recovered bronchoalveolar lavage (BAL) abnormal in this disease. In present study we have extended analysis surfactant components IPF to include major surfactant-associated protein, protein A (SP-A). SP-A has been reported be essential for formation tubular myelin, facilitate adsorption air/liquid interface, stimulate uptake inhibit secretion vitro. BAL 25 normal volunteers 42 patients with interstitial (ILD) was analyzed content ELISA phospholipids. changes were correlated histopathologic markers at open-lung biopsy, clinical status, survival. total (PL) reduced relative (p less than 0.0005). addition, percentage phosphatidyl-glycerol (% PG) decreased 0.0001), whereas phosphatidylcholine that saturated not altered. reduced, even when normalized amount (SP-A/PL) 0.007). reduction specific but also occurred other diseases.(ABSTRACT TRUNCATED AT 250 WORDS)