Hyaluronic Acid Versus Platelet-Rich Plasma: A Prospective, Double-Blind Randomized Controlled Trial Comparing Clinical Outcomes and Effects on Intra-articular Biology for the Treatment of Knee Osteoarthritis:
作者： Brian J. Cole , Vasili Karas , Kristen Hussey , David B. Merkow , Kyle Pilz
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摘要: Background:The use of platelet-rich plasma (PRP) for the treatment osteoarthritis (OA) has demonstrated mixed clinical outcomes in randomized controlled trials when compared with hyaluronic acid (HA), an accepted nonsurgical symptomatic OA. Biological analysis PRP anti-inflammatory effect on intra-articular environment.Purpose:To compare and biological effects injection those HA patients mild to moderate knee OA.Study Design:Randomized trial; Level evidence, 1.Methods:A total 111 unilateral OA received a series either leukocyte-poor or injections under ultrasound guidance. Clinical data were collected before at 4 time points across 1-year period. Synovial fluid was also proinflammatory markers 12 24 weeks after treatment. Seve...
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