摘要: Abstract A bidirectional interaction exists between sleep electroencephalogram (EEG) and endocrine activity in various species including humans. Various hormones (peptides, steroids) were shown to participate regulation. keyrole was for the reciprocal sleep-promoting growth hormone-releasing hormone (GHRH) sleep-impairing corticotropin-releasing (CRH). Changes GHRH:CRH ratio result changes of sleep-endocrine activity. There is good evidence that change this favor CRH contributes aberrances during aging depression. Besides GHRH ghrelin galanin promote SWS, whereas somatostatin another factor. NPY acts as a antagonist induces onset. Prolactin enhances rapid eve-movement (REMS) rats. SWS enhanced patients with prolactinoma. Other studies on influence prolactin human are lacking. controversy whether promotes REMS. In humans vasocactive intestinal polypeptide (VIP) appears play role temporal organization sleep, since after VIP administration NREMS-REMS cycle decelerated. Several neuroactive steroids (pregnenolone, progesterone, allopregnanolone, dehydroepiandrosterone) exert specific effects EEG via GABAA receptors. Cortisol enhance Finally gonadal Estrogen replacement therapy CRH-1 receptor antagonism depression beneficial clinical applications basic research presented here.
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