Association of microRNA-93, 190, 200b and receptor status in core biopsies from stage III breast cancer patients.
作者： Agnieszka Kolacinska , Jan Morawiec , Zofia Pawlowska , Janusz Szemraj , Bożena Szymanska
关键词:
摘要: Oncologists now favor more personalized treatment strategies in breast cancer patients. Gene expression analysis has been widely used, but less is known about epigenetic factors, for example, microRNAs (miRNAs). The aim of this study was to determine the relationship between selected miRNAs and receptor status core biopsies sampled before preoperative chemotherapy stage III locally advanced (LABC) In 37 LABC biopsies, three per sample were analyzed: hsa-miR-93-5p, hsa-miR-190a, hsa-miR-200b-3p, hsa-miR-103a-3p as an endogenous control (TaqMan® RT-PCR; Applied Biosystems). Receptor determined by a dedicated pathologist. Mann–Whitney U, Shapiro–Wilk, Levene's tests used compare related samples. Levels miRNA-93 differed significantly patients with different expressions ER (estrogen receptor) PR (progesterone receptor). Higher levels found ER-negative (p=0.0027) PR-negative p...
sci-hub.se 参考文章(29)
S. Rowell, M. C. King, B. Newman, J. Boyd, Inherited predisposition to breast and ovarian cancer. American Journal of Human Genetics. ,vol. 55, pp. 861- 865 ,(1994)
R. M. Hudziak, J. Schlessinger, A. Ullrich, Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH 3T3 cells Proceedings of the National Academy of Sciences of the United States of America. ,vol. 84, pp. 7159- 7163 ,(1987) , 10.1073/PNAS.84.20.7159
Penn Muluhngwi, Numan Al-Rayyan, Carolyn M. Klinge, Tissa T. Manavalan, Yun Teng, Lacey M. Litchfield, Reduced Expression of miR-200 Family Members Contributes to Antiestrogen Resistance in LY2 Human Breast Cancer Cells PLoS ONE. ,vol. 8, pp. e62334- ,(2013) , 10.1371/JOURNAL.PONE.0062334
Manfred Kaufmann, Gunter von Minckwitz, Jonas Bergh, Pier-Franco Conte, Sarah Darby, Wolfgang Eiermann, Antony Howell, Marion Kiechle, Davide Mauri, Hans-Jörg Senn, Giuseppe Viale, Sibylle Loibl, Breakthroughs in research and treatment of early breast cancer: an overview of the last three decades Archives of Gynecology and Obstetrics. ,vol. 288, pp. 1203- 1212 ,(2013) , 10.1007/S00404-013-3069-4
Ling Fang, William W. Du, Weining Yang, Zina Jeyapalan Rutnam, Chun Peng, Haoran Li, Yunxia Q. O'Malley, Ryan W. Askeland, Sonia Sugg, Mingyao Liu, Tanvi Mehta, Zhaoqun Deng, Burton B. Yang, MiR-93 enhances angiogenesis and metastasis by targeting LATS2 Cell Cycle. ,vol. 11, pp. 4352- 4365 ,(2012) , 10.4161/CC.22670
Chad V Pecot, Rajesha Rupaimoole, Da Yang, Rehan Akbani, Cristina Ivan, Chunhua Lu, Sherry Wu, Hee-Dong Han, Maitri Y Shah, Cristian Rodriguez-Aguayo, Justin Bottsford-Miller, Yuexin Liu, Sang Bae Kim, Anna Unruh, Vianey Gonzalez-Villasana, Li Huang, Behrouz Zand, Myrthala Moreno-Smith, Lingegowda S Mangala, Morgan Taylor, Heather J Dalton, Vasudha Sehgal, Yunfei Wen, Yu Kang, Keith A Baggerly, Ju-Seog Lee, Prahlad T Ram, Murali K Ravoori, Vikas Kundra, Xinna Zhang, Rouba Ali-Fehmi, Ana-Maria Gonzalez-Angulo, Pierre P Massion, George A Calin, Gabriel Lopez-Berestein, Wei Zhang, Anil K Sood, None, Tumour angiogenesis regulation by the miR-200 family Nature Communications. ,vol. 4, pp. 2427- 2427 ,(2013) , 10.1038/NCOMMS3427
Donald M. Black, Ellen Solomon, The search for the familial breast/ovarian cancer gene. Trends in Genetics. ,vol. 9, pp. 22- 26 ,(1993) , 10.1016/0168-9525(93)90068-S
Ailbhe M. McDermott, Nicola Miller, Deirdre Wall, Lorcan M. Martyn, Graham Ball, Karl J. Sweeney, Michael J. Kerin, Identification and Validation of Oncologic miRNA Biomarkers for Luminal A-like Breast Cancer PLoS ONE. ,vol. 9, pp. e87032- ,(2014) , 10.1371/JOURNAL.PONE.0087032
Matthew D. Galbraith, Aaron J. Donner, Joaquín M. Espinosa, CDK8: a positive regulator of transcription. Transcription. ,vol. 1, pp. 4- 12 ,(2010) , 10.4161/TRNS.1.1.12373
K.B. Horwitz, W.L. McGuire, Specific progesterone receptors in human breast cancer Steroids. ,vol. 25, pp. 497- 505 ,(1975) , 10.1016/0039-128X(75)90027-6