Decreased functional connectivity between ventral tegmental area and nucleus accumbens in Internet gaming disorder: evidence from resting state functional magnetic resonance imaging
作者： Jin-Tao Zhang , Shan-Shan Ma , Sarah W. Yip , Ling-Jiao Wang , Chao Chen
DOI: 10.1186/S12993-015-0082-8
关键词:
摘要: Internet gaming disorder (IGD) has become an increasing mental health problem worldwide. Decreased resting-state functional connectivity (rsFC) between the ventral tegmental area (VTA) and nucleus accumbens (NAcc) been found in substance use is thought to play important role development of addiction. However, rsFC VTA NAcc a non-substance addiction, such as IGD, not assessed previously. The current study aimed investigate: (1) if individuals with IGD exhibit alterations VTA-NAcc connectivity; (2) whether associated subjective craving. Thirty-five male participants 24 healthy control (HC) participated magnetic resonance imaging. Regions interest (left NAcc, right VTA) were selected based on literature defined by placing spheres centered Talairach Daemon coordinates. In comparison HCs, had significantly decreased NAcc. Resting-state strength was negatively correlated self-reported craving for Internet. These results suggest possible neural similarities addictions.
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