Recurring outbreaks of an infection apparently targeting immune function, and consequent unprecedented growth in medical admission and costs in the United Kingdom: a review.

摘要: Background: The National Health Service (NHS) in the UK has been beset by unprecedented growth emergency admissions to hospital which are specifically medical nature, while surgical and trauma only showing level of low expected from demographic change, or what is called ageing population. There never an adequate explanation for this dichotomy. An Infectious Basis: proposed infectious basis rests upon observation that occurs spurts occur approximately five years apart, albeit three between have also observed during 1990’s. It these driving long-term growth, rather than relatively minor interval spurts. These periods high characterized spikes all-cause mortality, typically result a 15% increases group specialties. However much higher seen particular conditions/diagnoses appear common Review Article Jones; BJMMR, 6(8): 735-770, 2015; no.BJMMR.2015.251 736 immune function via infection, inflammation autoimmunity. outbreaks can be across Europe, last commenced around Mar-02, Mar-05 Mar-10 with subsequent spread over next two years. middle had lowest increase deaths admissions. Implications: now overwhelming body evidence pointing recurring series infectious-like events. In UK, 2012/2013 outbreak led 45,000 extra 27 EU countries, each appears somewhere excess 467,000 deaths. tend earlier Denmark, Romania, Bulgaria Slovakia, they later Belgium, Greece Slovenia. Emphasis needs switch toward clinical studies screen population changes levels specific IgM IgG antibodies against range potential candidate organisms, post mortem examination tissues persons who die conditions such as neurological disorders including dementia Alzheimer’s; respiratory gastrointestinal tract diseases, cardio/vascular conditions. Conclusion: This new disease highly disruptive discovery involving fundamental health care policy, our understanding role exacerbation