Single-dose and steady-state kinetics of morphine and its metabolites in cancer patients--a comparison of two oral formulations
作者： J. Hasselström , J. Säwe , C. Bringel , N. Alexander , J. O. Svensson
DOI: 10.1007/BF00279975
关键词:
摘要: The single-dose and steady state kinetics of morphine given as controlled-release tablets (30 mg every 12 h) a solution (15 6 have been compared in 11 cancer patients with chronic pain. concentrations morphine, morphine-3-glucuronide (M3G), morphine-6-glucuronide (M6G) were analyzed by HPLC. There no significant differences between the mean M3G or M6G. tmax was 3.3 h for to 1.1 solution. After giving there significantly higher fluctuation index than after Urinary recovery at comparable two preparations, averages 57% 47%, respectively. Thus, major found pharmacokinetics its glucuronidated metabolites 30 15 h, except longer greater tablets.
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