Fine spatiotemporal structure of phase in human intracranial EEG

摘要: Objective: To transfer to the clinic for humans technology and theory high-resolution EEG analysis that have been developed in laboratory with animals. Methods: EEGs were recorded at high spatial resolution from a 1 X cm 8 electrode array on right inferior temporal gyrus of patient undergoing preoperative monitoring epilepsy surgery. Cosines fitted segments measure frequency phase compute location, size, latency, velocity, duration, recurrence rate radially symmetric patterns called cones. The Hilbert transform was also used get resolution. Results: In awake state, power spectral density (PSD) showed power-law decrease log 1/f(alpha), alpha similar 2, but peaks standard empirical ranges. beta gamma ranges had gradients conic form. Resetting these stable cones spatially coincident intermittent discontinuities ('phase slip') recurring theta rates. Cones half diameters 2 50+ mm; their durations distributions values ranging 6 300+ ms depending length window. slow wave sleep PSD decreased 3,with loss beta-gamma diminished or absent oscillations spatiotemporal structure. Conclusions: Spatiotemporal structures human rabbit striking similarities. only clear differences ascribable differing scales measurement. These fine lost sleep. Significance: structure indicates neocortical stability is sustained self-organized criticality; synaptic input state drives neocortex away criticality causing re-stabilizing 'neural avalanches'; allows return toward some added risk instability seizure. (c) 2006 International Federation Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.