Dynamic changes in extracellular release of GABA and glutamate in the lateral septum during social play behavior in juvenile rats: Implications for sex-specific regulation of social play behavior

摘要: Social play is a motivated and rewarding behavior that displayed by nearly all mammals peaks in the juvenile period. Moreover, social essential for development of skills impaired disorders like autism. We recently showed lateral septum (LS) involved regulation male female rats. The LS largely modulated GABA glutamate neurotransmission, but their role unknown. Here, we determined whether associated with changes extracellular release to what extent such modulate Using intracerebral microdialysis freely behaving rats, found no sex difference concentrations, concentrations are higher males than females under baseline conditions during play. This resulted glutamate/GABA concentration ratio vs. thus, an excitatory predominance males. Furthermore, both sexes significant increases LS. Pharmacological blockade GABA-A receptors bicuculline (100 ng/0.5 μl, 250 μl) dose-dependently decreased duration sexes. In contrast, pharmacological ionotropic (NMDA AMPA/kainate receptors) AP-5+CNQX (2mM+0.4mM/0.5 30 mM+3mM/0.5 females, did not alter Together, these data suggest neurotransmission sexes, while sex-specific behavior.