作者: Cristina Lemini , Consuelo Rubio-Póo , Griselda Silva , Juana Garcia-Mondragon , Elvira Zavala
DOI: 10.1016/0039-128X(93)90002-5
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摘要: Abstract The syntheses and characterizations of two new 17β-aminoestrogens, butolame [17β-(4-hydroxy-1-butylamino)-1, 3,5(10)-estratrien-3-ol] pentolame [17β-(5-hydroxy-1-pentylamino)-1,3,5(10)-estratrien-3-ol], are presented. Both compounds, when administered in single subcutaneous injections to male mice rats, produce dose-dependent increases blood clotting times that may last several days. estrogenic effects assessed by the vaginal cornification test relatively short duration.