MET molecular mechanisms and therapies in lung cancer.

作者: Ryan E. Lawrence , Ravi Salgia

DOI: 10.4161/CAM.4.1.10973

关键词:

摘要: … This review discusses the role of MET in oncogenesis—especially lung cancer. Attention is … a 2–10-fold increase in MET expression when compared with adjacent normal tissue. Of note…

参考文章(54)
Martin Sattler, Patrick C. Ma, Ravi Salgia, Therapeutic Targeting of the Receptor Tyrosine Kinase Met Cancer treatment and research. ,vol. 119, pp. 121- 138 ,(2004) , 10.1007/1-4020-7847-1_7
L. Naldini, K.M. Weidner, E. Vigna, G. Gaudino, A. Bardelli, C. Ponzetto, R.P. Narsimhan, G. Hartmann, R. Zarnegar, G.K. Michalopoulos, Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor. The EMBO Journal. ,vol. 10, pp. 2867- 2878 ,(1991) , 10.1002/J.1460-2075.1991.TB07836.X
J Wojta, T Nakamura, A Fabry, P Hufnagl, R Beckmann, K McGrath, BR Binder, Hepatocyte growth factor stimulates expression of plasminogen activator inhibitor type 1 and tissue factor in HepG2 cells. Blood. ,vol. 84, pp. 151- 157 ,(1994) , 10.1182/BLOOD.V84.1.151.151
Patrick C Ma, Gautam Maulik, James Christensen, Ravi Salgia, c-Met: Structure, functions and potential for therapeutic inhibition Cancer and Metastasis Reviews. ,vol. 22, pp. 309- 325 ,(2003) , 10.1023/A:1023768811842
Gautam Maulik, Takashi Kijima, Geoffrey I. Shapiro, Bruce E. Johnson, Sudip K. Ghosh, Patrick C. Ma, Ravi Salgia, Erik Schaefer, Elena Tibaldi, Jeffrey Lin, Modulation of the c-Met/hepatocyte growth factor pathway in small cell lung cancer. Clinical Cancer Research. ,vol. 8, pp. 620- 627 ,(2002)
Jeffrey G. Supko, Robert L. Hickman, Michael R. Grever, Louis Malspeis, Preclinical pharmacologic evaluation of geldanamycin as an antitumor agent. Cancer Chemotherapy and Pharmacology. ,vol. 36, pp. 305- 315 ,(1995) , 10.1007/BF00689048
Gautam Maulik, Amol Shrikhande, Takashi Kijima, Patrick C. Ma, Paul T. Morrison, Ravi Salgia, Role of the hepatocyte growth factor receptor, c-Met, in oncogenesis and potential for therapeutic inhibition Cytokine & Growth Factor Reviews. ,vol. 13, pp. 41- 59 ,(2002) , 10.1016/S1359-6101(01)00029-6
Daniel Besser, Alberto Bardelli, Svetlana Didichenko, Marcus Thelen, Paolo M Comoglio, Carola Ponzetto, Yoshikuni Nagamine, Regulation of the urokinase-type plasminogen activator gene by the oncogene Tpr-Met involves GRB2 Oncogene. ,vol. 14, pp. 705- 711 ,(1997) , 10.1038/SJ.ONC.1200879
Michael Dean, Morag Park, Michelle M. Le Beau, Terry S. Robins, Manuel O. Diaz, Janet D. Rowley, Donald G. Blair, George F. Vande Woude, The human met oncogene is related to the tyrosine kinase oncogenes Nature. ,vol. 318, pp. 385- 388 ,(1985) , 10.1038/318385A0
G. Maulik, P. Madhiwala, S. Brooks, P. C. Ma, T. Kijima, E. V. Tibaldi, E. Schaefer, K. Parmar, R. Salgia, Activated c-Met signals through PI3K with dramatic effects on cytoskeletal functions in small cell lung cancer. Journal of Cellular and Molecular Medicine. ,vol. 6, pp. 539- 553 ,(2002) , 10.1111/J.1582-4934.2002.TB00453.X