Encapsulins: molecular biology of the shell

作者: Robert J Nichols , Caleb Cassidy-Amstutz , Thawatchai Chaijarasphong , David F Savage , None

DOI: 10.1080/10409238.2017.1337709

关键词:

摘要: Compartmentalization is both a fundamental principle of cellular organization and an emerging theme in prokaryotic biology. Work the past few decades has shown that protein-based organelles called microcompartments enhance function encapsulated cargo proteins. More recently, repertoire known expanded beyond to include new class smaller proteinaceous compartments, termed nanocompartments (also as encapsulins). Nanocompartments are icosahedral capsids less complex than microcompartments. Encapsulins formed by single species shell protein self-assembles typically encapsulates only one type protein. Significant progress been made understanding structure nanocompartment shells loading interior. Recent analysis also demonstrated prevalence encapsulin genes throughout genomes documented large diversity proteins with variety novel functions, suggesting play important role many microbes. Here we review current highlight exciting open questions physiological significance.

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