Expression of the human beta-amyloid protein of Alzheimer's disease specifically in the brains of transgenic mice.
作者： F.A. Sandhu , M. Salim , S.B. Zain
DOI: 10.1016/S0021-9258(18)54637-8
关键词:
摘要: The human beta-amyloid protein is deposited in senile plaques and the cerebro-vasculature of people with Alzheimer's disease Down's syndrome. precise role pathology presently unknown. To study properties vivo, we generated transgenic mice that harbor gene for carboxyl-terminal 100 amino acids amyloid precursor protein, beginning region, under control JC viral early region promoter. mRNA expressed exclusively brain tissue. Further, demonstrate increased levels immunoreactivity on fixed These animals will be useful as a model to deposition its consequences.
sci-hub.st 参考文章(30)
R J Frisque, G L Bream, M T Cannella, Human polyomavirus JC virus genome. Journal of Virology. ,vol. 51, pp. 458- 469 ,(1984) , 10.1128/JVI.51.2.458-469.1984
F. L. Margolis, M. Grillo, Use of reverse transcriptase polymerase chain reaction to monitor expression of intronless genes. BioTechniques. ,vol. 9, pp. 262- 268 ,(1990)
J. D. Buxbaum, S. E. Gandy, P. Cicchetti, M. E. Ehrlich, A. J. Czernik, R. P. Fracasso, T. V. Ramabhadran, A. J. Unterbeck, P. Greengard, Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 87, pp. 6003- 6006 ,(1990) , 10.1073/PNAS.87.15.6003
Jae-young Koh, Linda L. Yang, Carl W. Cotman, β-Amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage Brain Research. ,vol. 533, pp. 315- 320 ,(1990) , 10.1016/0006-8993(90)91355-K
H. Erlich, D. Gelfand, J. Sninsky, Recent advances in the polymerase chain reaction Science. ,vol. 252, pp. 1643- 1651 ,(1991) , 10.1126/SCIENCE.2047872
A. D. DAYAN, Comparative neuropathology of ageing. Studies on the brains of 47 species of vertebrates. Brain. ,vol. 94, pp. 31- 42 ,(1971) , 10.1093/BRAIN/94.1.31
Z. Ali-Khan, R. Quirion, Y. Robitaille, K. Alizadeh-Khiavi, T. Du, Evidence for increased amyloid enhancing factor activity in Alzheimer brain extract. Acta Neuropathologica. ,vol. 77, pp. 82- 90 ,(1988) , 10.1007/BF00688246
Nobuya Kitaguchi, Yasuyuki Takahashi, Yasuo Tokushima, Satoshi Shiojiri, Hirataka Ito, Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity Nature. ,vol. 331, pp. 530- 532 ,(1988) , 10.1038/331530A0
George G. Glenner, Caine W. Wong, Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein Biochemical and Biophysical Research Communications. ,vol. 120, pp. 885- 890 ,(1984) , 10.1016/S0006-291X(84)80190-4
D. Selkoe, D. Bell, M. Podlisny, D. Price, L. Cork, Conservation of brain amyloid proteins in aged mammals and humans with Alzheimer's disease Science. ,vol. 235, pp. 873- 877 ,(1987) , 10.1126/SCIENCE.3544219