IFI16 is an innate immune sensor for intracellular DNA.

作者: Leonie Unterholzner , Sinead E Keating , Marcin Baran , Kristy A Horan , Søren B Jensen

DOI: 10.1038/NI.1932

关键词:

摘要: … IFI16 was able to directly bind the viral DNAs in vitro, we expressed the HIN domains of IFI16 in … to assess in vitro binding between viral DNA and purified IFI16 HIN domains. Biotinylated …

参考文章(42)
Luke A. J. O'Neill, Andrew G. Bowie, The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling Nature Reviews Immunology. ,vol. 7, pp. 353- 364 ,(2007) , 10.1038/NRI2079
Yu-Hsin Chiu, John B. MacMillan, Zhijian J. Chen, RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I Pathway Cell. ,vol. 138, pp. 576- 591 ,(2009) , 10.1016/J.CELL.2009.06.015
Juliane Lippmann, Stefan Rothenburg, Nikolaus Deigendesch, Julia Eitel, Karolin Meixenberger, Vincent van Laak, Hortense Slevogt, Philippe Dje N'Guessan, Stefan Hippenstiel, Trinad Chakraborty, Antje Flieger, Norbert Suttorp, Bastian Opitz, IFNβ responses induced by intracellular bacteria or cytosolic DNA in different human cells do not require ZBP1 (DLM‐1/DAI) Cellular Microbiology. ,vol. 10, pp. 2579- 2588 ,(2008) , 10.1111/J.1462-5822.2008.01232.X
Veit Hornung, Franz Bauernfeind, Annett Halle, Eivind O Samstad, Hajime Kono, Kenneth L Rock, Katherine A Fitzgerald, Eicke Latz, Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization Nature Immunology. ,vol. 9, pp. 847- 856 ,(2008) , 10.1038/NI.1631
Zachary J. Roberts, Nadege Goutagny, Pin-Yu Perera, Hiroki Kato, Himanshu Kumar, Taro Kawai, Shizuo Akira, Ram Savan, David van Echo, Katherine A. Fitzgerald, Howard A. Young, Lai-Ming Ching, Stefanie N. Vogel, The chemotherapeutic agent DMXAA potently and specifically activates the TBK1–IRF-3 signaling axis Journal of Experimental Medicine. ,vol. 204, pp. 1559- 1569 ,(2007) , 10.1084/JEM.20061845
Jennifer Lund, Ayuko Sato, Shizuo Akira, Ruslan Medzhitov, Akiko Iwasaki, Toll-like Receptor 9–mediated Recognition of Herpes Simplex Virus-2 by Plasmacytoid Dendritic Cells Journal of Experimental Medicine. ,vol. 198, pp. 513- 520 ,(2003) , 10.1084/JEM.20030162
Andrea Ablasser, Franz Bauernfeind, Gunther Hartmann, Eicke Latz, Katherine A Fitzgerald, Veit Hornung, RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate. Nature Immunology. ,vol. 10, pp. 1065- 1072 ,(2009) , 10.1038/NI.1779
Simon B. Rasmussen, Louise N. Sørensen, Lene Malmgaard, Nina Ank, Joel D. Baines, Zhijian J. Chen, Søren R. Paludan, Type I Interferon Production during Herpes Simplex Virus Infection Is Controlled by Cell-Type-Specific Viral Recognition through Toll-Like Receptor 9, the Mitochondrial Antiviral Signaling Protein Pathway, and Novel Recognition Systems Journal of Virology. ,vol. 81, pp. 13315- 13324 ,(2007) , 10.1128/JVI.01167-07
Simon Rothenfusser, Nadege Goutagny, Gary DiPerna, Mei Gong, Brian G. Monks, Annett Schoenemeyer, Masahiro Yamamoto, Shizuo Akira, Katherine A. Fitzgerald, The RNA Helicase Lgp2 Inhibits TLR-Independent Sensing of Viral Replication by Retinoic Acid-Inducible Gene-I Journal of Immunology. ,vol. 175, pp. 5260- 5268 ,(2005) , 10.4049/JIMMUNOL.175.8.5260
Hendrik Poeck, Michael Bscheider, Olaf Gross, Katrin Finger, Susanne Roth, Manuele Rebsamen, Nicole Hannesschläger, Martin Schlee, Simon Rothenfusser, Winfried Barchet, Hiroki Kato, Shizuo Akira, Satoshi Inoue, Stefan Endres, Christian Peschel, Gunther Hartmann, Veit Hornung, Jürgen Ruland, Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1|[beta]| production Nature Immunology. ,vol. 11, pp. 63- 69 ,(2010) , 10.1038/NI.1824