Contributions of upper gut hormones and motility to the energy intake-suppressant effects of intraduodenal nutrients in healthy, lean men - a pooled-data analysis.

摘要: We have previously identified pyloric pressures and plasma cholecystokinin (CCK) concentrations as independent determinants of energy intake following administration intraduodenal lipid intravenous CCK. evaluated in healthy men whether these parameters also determine response to protein, whether, across the nutrients, any predominant gastrointestinal (GI) factors exist, or many make small contributions. Data from nine published studies, which antropyloroduodenal pressures, GI hormones, /appetite perceptions were measured during protein infusions, pooled. In all studies was quantified immediately after infusions. Specific variables for inclusion a mixed-effects multivariable model determination predictors chosen assessment collinearity, within-subject correlations between determined using bivariate analyses adjusted repeated measures. models based on there significant effects amplitude antral pressure waves, premeal glucagon-like peptide-1 (GLP-1) time-to-peak GLP-1 concentrations, AUC bloating scores (P < 0.05), trends basal (BPP), duodenal peak CCK hunger nausea (0.05 P ≤ 0.094), be subsequent intake. including only BPP an determinant 0.05). No single parameter models, relatively small. Taken together, while mechanisms contribute regulation acute by their contribution latter is much less. Moreover, are likely reflect small, cumulative contributions range interrelated factors.