Global profiling of TSEC proliferative potential by the use of a reporter mouse for proliferation.
作者： Paolo Oliva , Chiara Roncoroni , Enrico Radaelli , Electra Brunialti , Nicoletta Rizzi
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摘要: Introduction:“Tissue-selective estrogen complex” or TSEC is a novel concept of replacement therapy for the postmenopause based on combined use estrogens and selective receptor modulators (SERMs). The aim this study was to exploit potential transgenic mouse where luciferase expression associated with cell proliferation (the MITO-luc mouse) investigate in reproductive nonreproductive tissues mice exposed repetitive treatments TSEC.Material Methods:Ovariectomized MITO-Luc were subjected daily oral treatment bazedoxifene, conjugated (CE), TSEC, raloxifene 21 days. During treatment, proliferative effects monitored by bioluminescence-based vivo imaging. At end euthanized assessed selected quantitative analysis activity immunohistochemistry (IHC).Results:In uterus with...
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