Nϵ-Carboxymethyl-Lysine Deteriorates Vascular Calcification in Diabetic Atherosclerosis Induced by Vascular Smooth Muscle Cell-Derived Foam Cells.
作者： Sui-Ning Xu , Xin Zhou , Cun-Jun Zhu , Wei Qin , Jie Zhu
关键词:
摘要: Nϵ-carboxymethyl-lysine (CML), an advanced glycation end product, is involved in vascular calcification (VC) diabetic atherosclerosis. This study aimed to investigate the effects of CML on VC atherosclerosis induced by smooth muscle cell (VSMC)-derived foam cells. Human studies, animal studies and were performed. The human results from 100 patients revealed a poor blood glucose lipid status more severe coronary lesions stenosis with artery disease diabetes mellitus. Intraperitoneal injection streptozotocin combined high-fat diet was used build model ApoE-/- mice. indicated that accelerated progression accelerating accumulation VSMC-derived cells illustrated apoptosis aggravated calcification. Consistent this finding, calcium content expression levels alkaline phosphatase, bone morphogenetic protein 2 runt-related transcription factor significantly elevated A7r5 treated oxidation-low-density lipoprotein CML. Thus, we concluded promoted aggravate atherosclerosis, providing evidence for contribution VC.
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