Natural Product-Derived Treatments of Neuropsychiatric Disorders: Review of Progress and Recommendations

摘要: Abstract Most currently used psychotropic agents have limited efficacy, significant side-effect and toxicity problems, are unavailable to approximately 80% of the World's population. The development efficacious safe medications based on naturally occurring substances in non-allopathic healing traditions would represent a contribution global mental health care. Rigorous empirical validation indigenous treatments for neuopsychiatric symptoms syndromes is necessary ensure that goals safety efficacy achieved. With these view, present monograph reviews discusses important historical, scientific, cross-cultural legal-regulatory aspects as neuropsychiatric disorders. design systematic review published scientific literature controlled studies (using Napralert database) described. Limitations identified possible solutions Significant findings discussed developed into framework further analysis. Six CNS activity categories selected in-depth because their central relevance common or syndromes. In main body synoptic reviews, including summary exhibits, provided current status recent research, in-vitro, animal human clinical trials investigating treatment seizure disorders, schizophrenia, dementia age-related cognitive decline, unipolar depression other mood anxiety states, substance abuse dependence. Substantial evidence advanced many natural products employed systems medicine treat neuropsychiatrie Many empirically validated appear efficacies comparable superior synthetic agents. concludes with recommendations offered facilitating improved networking, accelerating promising research directions, enhancing quality standards ethnopharmacologic investigations putative