Prostate cancer and prediagnostic levels of serum vitamin D metabolites (Maryland, United States)

摘要: An hypothesis has been forwarded linking prostate cancer to low serum levels of vitamin D metabolites. We sought test this using sera obtained in a large, prospective cohort study. A bank Washington County, Maryland (United States) stored from 20,305 county residents during blood collection campaign undertaken August through November 1974. studied 61 who were diagnosed with the period 1980 1992. Each case was matched two controls on age (+/- 1 yr) and race. Controls had donated same blood-collection not Serum metabolites did differ significantly between cases controls. Mean 25-hydroxyvitamin (25-D) 34.3 ng/ml 33.2 ng/ml, mean 1,25-dihydroxyvitamin (1,25-D) 41.0 pg/ml 40.1 pg/ml, controls, respectively. No statistically significant trends or differences found an analysis by quintile level. also observe association be strongest among older men more severe disease, as previously reported. In summary, although our study's power limited, findings provide little support for that metabolite are associated strongly subsequent risk cancer.