The role of bax in pmc-f induced cell death mechanism in HCT116 colon carcinoma cell lines

作者: Elif Levent

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摘要: In a previous study reported from our lab, 2 analogous of Pramanicin (PMC); PMC-A and PMC-F were found to be the most toxic drugs in HCT116 colon carcinoma cell line, among 9 analogues. this study, cytotoxicity has been compared death signaling pathways have identified WT Bax-/- cells. cells exhibited resistance early times drug treatment, followed similar response with was more effective than inducing initial cleavage caspase-3, -9 -8. Therefore, used further experiments. To understand role MAP kinases induced apoptosis, their phosphorylation levels investigated. The results showed that higher level ERK 1/2 JNK phosphorylations. Also, presented an increasing p38 sustained longer We also demonstrated ROS production both lines, but less delayed manner These data indicate may stand for new potential anti-cancer treatment cancer. Moreover, might key mechanism which determines MAPK earlier apoptosis.

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