Role of Interleukin-22 in chronic liver injury.
作者： Rodrigo F. Carmo , Maria S.M. Cavalcanti , Patrícia Moura
DOI: 10.1016/J.CYTO.2016.08.023
关键词:
摘要: Liver fibrosis is the result of an exacerbated wound-healing response associated with chronic liver injury. Advanced results in cirrhosis, failure, and portal hypertension frequently requires transplantation. The host immune has important role driving deposition by activating hepatic stellate cells (HSCs). Interleukin-22 (IL-22) a cytokine that plays key promoting antimicrobial immunity tissue repair at barrier surfaces. Data from literature suggest IL-22 protective reducing some pathological conditions, however are contradictory. This review highlights current knowledge IL-22' injury, as well its therapeutic potential for treatment
sci-hub.se 参考文章(92)
Paul J. Chestovich, Yoichiro Uchida, William Chang, Mark Ajalat, Charles Lassman, Robert Sabat, Ronald W. Busuttil, Jerzy W. Kupiec-Weglinski, Interleukin-22 Transplantation. ,vol. 93, pp. 485- 492 ,(2012) , 10.1097/TP.0B013E3182449136
David A Brenner, Reversibility of liver fibrosis. Gastroenterología y Hepatología. ,vol. 9, pp. 737- 739 ,(2013)
Kerstin Wolk, Ellen Witte, Ute Hoffmann, Wolf-Dietrich Doecke, Stefanie Endesfelder, Khusru Asadullah, Wolfram Sterry, Hans-Dieter Volk, Bianca Maria Wittig, Robert Sabat, IL-22 Induces Lipopolysaccharide-Binding Protein in Hepatocytes: A Potential Systemic Role of IL-22 in Crohn’s Disease Journal of Immunology. ,vol. 178, pp. 5973- 5981 ,(2007) , 10.4049/JIMMUNOL.178.9.5973
Mark S. Wilson, Carl G. Feng, Daniel L. Barber, Felix Yarovinsky, Allen W. Cheever, Alan Sher, Michael Grigg, Mary Collins, Lynette Fouser, Thomas A. Wynn, Redundant and Pathogenic Roles for IL-22 in Mycobacterial, Protozoan, and Helminth Infections Journal of Immunology. ,vol. 184, pp. 4378- 4390 ,(2010) , 10.4049/JIMMUNOL.0903416
Stephanie L Sanos, Viet L Bui, Arthur Mortha, Karin Oberle, Charlotte Heners, Caroline Johner, Andreas Diefenbach, RORγt and commensal microflora are required for the differentiation of mucosal interleukin 22–producing NKp46 + cells Nature Immunology. ,vol. 10, pp. 83- 91 ,(2009) , 10.1038/NI.1684
Svetlana Radaeva, Hongna Pan, Feng Hong, Bin Gao, Hydrodynamic gene delivery of interleukin-22 protects the mouse liver from concanavalin A-, carbon tetrachloride-, and Fas ligand-induced injury via activation of STAT3. Cellular & Molecular Immunology. ,vol. 1, pp. 43- 49 ,(2004)
Paolo Fagone, Katia Mangano, Antonio Pesce, Teresa Rosanna Portale, Stefano Puleo, Ferdinando Nicoletti, Emerging therapeutic targets for the treatment of hepatic fibrosis. Drug Discovery Today. ,vol. 21, pp. 369- 375 ,(2016) , 10.1016/J.DRUDIS.2015.10.015
Xiaoni Kong, Dechun Feng, Stephanie Mathews, Bin Gao, Hepatoprotective and anti-fibrotic functions of interleukin-22: Therapeutic potential for the treatment of alcoholic liver disease Journal of Gastroenterology and Hepatology. ,vol. 28, pp. 56- 60 ,(2013) , 10.1111/JGH.12032
Dong Zhao, Xi-Dai Long, Tian-Fei Lu, Tao Wang, Wei-Wei Zhang, Yi-Xiao Liu, Xiao-Lan Cui, Hui-Juan Dai, Feng Xue, Qiang Xia, Metformin decreases IL-22 secretion to suppress tumor growth in an orthotopic mouse model of hepatocellular carcinoma. International Journal of Cancer. ,vol. 136, pp. 2556- 2565 ,(2015) , 10.1002/IJC.29305
Aijaz Ahmed, Robert J. Wong, Stephen A. Harrison, Nonalcoholic Fatty Liver Disease Review: Diagnosis, Treatment, and Outcomes Clinical Gastroenterology and Hepatology. ,vol. 13, pp. 2062- 2070 ,(2015) , 10.1016/J.CGH.2015.07.029