Early adolescent language development following intrathecal chemotherapy for acute lymphoblastic leukaemia

摘要: AbstractPurpose: Central nervous system (CNS) prophylaxis in the treatment of childhood acute lymphoblastic leukaemia (ALL) is routinely achieved through intrathecal chemotherapy (ITC). The presence high level language deficits older children who received CNS-directed ITC for ALL early yet to be elucidated, with previous research suggesting that may appear later survivors’ development at an age when these skills typically emerge.Method: A test battery covering foundational and higher-order was administered five participants (aged 10–15 years) a history ALL. Conversion each child’s performance scores z allowed clinical interpretation data across areas tested.Result: Foundational were, general, no concern. Three presented clinically impaired including resolving ambiguity, making...