Synthesis of the first examples of iminosugar clusters based on cyclopeptoid cores

摘要: Cyclic N-propargyl α-peptoids of various sizes were prepared by way macrocyclizations linear N-substituted oligoglycines. These compounds used as molecular platforms to synthesize a series iminosugar clusters with different valency and alkyl spacer lengths means Cu(I)-catalysed azide–alkyne cycloadditions. Evaluation these α-mannosidase inhibitors led significant multivalent effects further demonstrated the decisive influence scaffold rigidity on binding affinity enhancements.